I keep a record of my stats on long trips, and with this year's trip now over I can share some info. I don't keep track of side trips w/o the camper but I doubt we are unhitched more than 5% of the total mileage. Many sightseeing trips are between campsites so the camper goes with us. But, the unhitched miles @ 17.5 mpg do skew the numbers upward slightly.
3414 miles factory tune, mostly flat territory (MD to FL back to southern PA), all on 87 octane gas. Average mpg for that section was 7.2.
379 miles factory tune, hills of PA, two tanks of gas 91 and 93 octane. Average mpg was 8.8. Since this was only 2 tanks I'm sure there is some error in that number. It may include some non-towing sightseeing.
1825 miles tow tune, from hilly to steep mountains (PA, upstate NY, VT, Acadia in ME, NH, through PA to MD), average octane was about 92. Average mpg was 8.1.
Mpg increase with the tow tune was 12.5% while the cost increase was 16.8% (the two tanks with higher octane and factory tune aren't included in these numbers). This is really comparing apples to oranges though, with most of the terrain so flat before and hilly to very steep after. Yet that makes the mpg increase more interesting.
Future steps include more towing miles with higher octane and the factory tune, daily driving with higher octane with and w/o the tow tune, daily driving with the performance tune, and daily driving with the economy tune.