Different manufacturers have slightly different axle ratios, but in general they are close to:
3.3-3.4, higher speeds possible, less torque at low speeds, best mpg
3.7, best middle-of-the-road gearing, better low-end torque but still decent mpg
4.1, best torque for heavy loads but worst mpg, very high rpms at highway speed
For the heavy duty towing vehicle you describe I would go with the 3.31 for use with the pod, it will only be about 3000 pounds when loaded. My Suburban is similar in specs with the heavy duty towing package, 6 speed tranny, 3.42 rear and I've never wished I had a different ratio. Very happy to get a little better mpg day to day.