Lots of folks here with F series pickups who can probably help with the setup details. For a general "theory of operation" check out this write up:
The brake controller outputs a voltage that varies depending on how much braking action is needed. In modern controllers that voltage is proportional to the rate at which you are slowing the tow vehicle down so the trailer brakes are following along with how aggressively you're using the TV brakes.
You will have a couple of adjustments to make in the controller setup which usually only has to be done once unless you change trailers or really change the trailer loading a lot. The other thing you will want to know how to do is how to activate the controller manually so you can test the trailer brakes without operating the tow vehicle brakes before hitting the road. Otherwise it can be hard to tell if the trailer brakes are working because the TV brakes have much more capacity.